Atorvastatin
HYPOLIPIDEMIC DRUGSUses of Atorvastatin
- Atorvastatin is primarily used to reduce low-density lipoprotein (LDL) cholesterol and triglycerides in the blood, while increasing high-density lipoprotein (HDL) cholesterol.
- Atorvastatin is primarily used to reduce low-density lipoprotein (LDL) cholesterol and triglycerides in the blood, while increasing high-density lipoprotein (HDL) cholesterol.
- It is prescribed to lower the risk of stroke, heart attack, and other heart complications, especially in people with risk factors such as type 2 diabetes, coronary heart disease, or other conditions.
- It is used to treat various types of dyslipidemia, including primary hypercholesterolemia, mixed dyslipidemia, and homozygous familial hypercholesterolemia.
Atorvastatin helps in slowing the progression of atherosclerosis, a condition characterized by the hardening and narrowing of the arteries due to cholesterol and plaque build-up.
Side effects of Atorvastatin
The side effects of Atorvastatin are:
- Nausea
- Constipation
- Flatulence
- Diarrhoea
- Indigestion
- Joint pain
- Muscle pain
- Back pain
How Atorvastatin works
- Atorvastatin works by inhibiting an enzyme in the liver known as HMG-CoA reductase. Here’s a detailed explanation of its mechanism of action:
Atorvastatin blocks the action of HMG-CoA reductase, an enzyme involved in the production of cholesterol in the liver. This enzyme is crucial for the conversion of HMG-CoA to mevalonate, a key step in the biosynthesis of cholesterol. - By inhibiting this enzyme, atorvastatin reduces the synthesis of cholesterol in the liver. This leads to a decrease in the overall level of cholesterol in the blood.
- With reduced cholesterol synthesis, the liver cells increase the number of LDL receptors on their surface. These receptors bind to LDL cholesterol particles (often referred to as "bad cholesterol") and remove them from the bloodstream.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Atorvastatin is available for use via the oral route (tablets, capsules).
Age and Dose Restrictions
- Atorvastatin is meant for adults and children above 10 years of age.
Contraindications
- Atorvastatin is contraindicated in patients with known allergies to atorvastatin and who have severe kidney or liver issues.
Other Medications To Avoid With This Medicine
- Avoid using antibiotics, antifungals, HIV medications, hepatitis C medications, anti-arthritis medications, heart rate control medications, and antihypertensive medications while on Atorvastatin. Always consult your doctor before taking any prescription or over-the-counter medications.
Overdose and Missed Dose
- In case of an overdose of Atorvastatin, inform your doctor and follow the advice accordingly.
- If you forget an Atorvastatin dose, take it as soon as you remember. But avoid repeating the dose.
Use In Driving And Operating Machinery
- Atorvastatin may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.
Use in Pregnancy and Lactation
- Atorvastatin is not recommended during pregnancy or breastfeeding.
Special Dietary & Lifestyle Recommendation
- Avoid alcohol when you are taking Atorvastatin.
- People dealing with a history of high cholesterol are advised to contemplate lifestyle adjustments, including dietary modifications such as adopting a low-cholesterol and low-fat diet along with Atorvastatin.
- Avoid grapefruit juice when taking Atorvastatin as it can affect the working of atorvastatin.
Frequently asked questions
1. How much time does Atorvastatin take to work?
Atorvastatin starts showing its effect within a few hours after ingestion.
2. What warnings and precautions should I take while taking Atorvastatin?
Notify your doctor of your use of Atorvastatin before any forthcoming surgical interventions or emergency hospital admissions, as it may elevate the potential for bleeding.
3. Can I stop taking Atorvastatin if I feel healthy?
Do not stop taking it without consulting your doctor, even if you feel healthy.
4. Is it safe for patients with kidney or liver issues?
Consult your doctor before taking this, if you have kidney or liver issues to ensure its safety and proper dosage.
5. Will taking Atorvastatin lead to an increase in my risk of diabetes?
Atorvastatin, commonly known as Lipitor, is a statin used to lower cholesterol levels. While some studies suggest a small increase in diabetes risk with statins, the absolute risk remains low. If you are concerned about the risk of getting diabetes, consult your doctor before you take this tablet.
6. Does Atorvastatin cause weight loss?
Atorvastatin is not associated with weight loss. However, some people may experience changes in appetite while taking statins.
7. Is atorvastatin 20 mg a blood thinner?
Atorvastatin is not a blood thinner. It works by lowering cholesterol levels and reducing the risk of heart attacks and strokes.
8. What is the best time to take atorvastatin?
You can take atorvastatin either in the morning or at night. Consistency matters more than the specific time due to its long half-life.
9. Does Atorvastatin cause memory loss?
Some studies suggest a link between statins (including atorvastatin) and memory issues, but this remains controversial. If you experience memory problems, consult your doctor.
10. Can Atorvastatin be prescribed to children?
Atorvastatin is generally not prescribed to children under 10 years of age.
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