Artesunate
Uses of Artesunate
The primary use of Artesunate is to manage severe malaria, including cerebral malaria. It is an antimalarial medication and is particularly effective against the parasite Plasmodium falciparum, including strains that are resistant to other medicines. It is an antimalarial medication.
Additionally, Artesunate is used in cases of uncomplicated P. falciparum malaria in areas where resistance to other antimalarials is prevalent. Occasionally, it may be used for less severe forms of malaria when other treatments are not available or not tolerated.
Side effects of Artesunate
Headache
Dizziness
Nausea and vomiting
Abdominal pain
Skin rash
How Artesunate works
Artesunate is an antimalarial medication.
It contains an endoperoxide bridge structure that plays a fundamental role in its action against malaria. This structure assists in releasing free radicals that attach to and damage specific proteins in the malaria parasites, mainly the sarco/endoplasmic reticulum calcium ATPase (SERCA). This damage disrupts the metabolic functions of the parasite, especially during its trophozoite and schizont stages, leading to the ultimate death of the parasite.
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Expert Advice
Dosage Forms Available
Artesunate can be taken orally (tablet) and intravenously or intramuscularly (injection).
Age and Dose Restrictions
Artesunate can be administered to adults and children.
Contraindications
Artesunate is contraindicated in patients with known hypersensitivity to artemisinins. Patients with severe liver impairment must also refrain from taking this medicine.
Other Medications to Avoid
Artesunate can interact with medications metabolised by CYP2A6 (such as halothane and valproic acid) and other antimalarials (such as mefloquine and quinine).
Overdose and Missed Dose
Overdosing on Artesunate may result in severe side effects such as anemia, hemolysis, and allergic reactions. If you suspect an overdose, seek immediate medical attention.
In case of a missed dose, take the medicine as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of fluids can help manage gastrointestinal disturbances such as nausea, vomiting, and diarrhoea.
Resting in a quiet, dimly lit room can alleviate headaches and dizziness.
Use in Driving and Operating Machinery
Artesunate does not typically interfere with your ability to drive or operate heavy machinery. However, if you experience side effects like dizziness or blurred vision, it would be best to avoid such activities.
Use in Pregnancy and Lactation
It should only be used in pregnancy if the potential benefits outweigh the risks. It may be used during the second and third trimesters and while breastfeeding. However, you must always consult your doctor before using this medicine during pregnancy or breastfeeding.
Caution in Other Conditions
Patients with liver impairment should exercise caution when taking Artesunate.
Regular monitoring of liver function is advised in these patients.
Special Dietary and Lifestyle Recommendations
Limiting mosquito exposure by using protective clothing, screens, insect repellent, and mosquito nets can help prevent malaria infection.
Regular health check-ups can help monitor your condition and ensure the medication is working effectively.
If you are travelling to a malaria-endemic region, take precautions recommended by your doctor to prevent infection.
Frequently asked questions
Is Artesunate a type of steroid?
No, Artesunate is not a steroid. It is a type of antimalarial medication and is derived from the plant Artemisia annua.
Will Artesunate have any effect on fertility?
Artesunate is not directly associated with affecting fertility. However, it is always advised to discuss with your doctor if you are planning to become pregnant or father a child while taking any medication.
Is it safe to take Artesunate every day?
Artesunate should be taken exactly as prescribed by your doctor. The duration and dosage will depend on the severity of the malaria infection. It should not be self-administered without medical guidance.
How quickly does Artesunate start working?
Artesunate acts quickly in the body and begins working within 1-2 hours of administration, as per its pharmacokinetic properties.
What is the optimal time to administer Artesunate?
The best time to take Artesunate will be determined by your doctor based on your specific condition and overall health status.
What is the typical treatment duration with Artesunate?
The duration of treatment with Artesunate is generally determined by your doctor based on the severity of the malaria infection.
Is Artesunate available over the counter, or do I need a prescription?
Artesunate is generally not available without a prescription due to its powerful antimalarial properties and potential for misuse.
Artesunate in other salts
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