Amikacin
Uses of Amikacin
Amikacin is used to manage serious bacterial infections in various parts of the body. It belongs to the class of medications known as aminoglycoside antibiotics.
Additionally, it is prescribed for managing respiratory tract infections, urinary tract infections, abdominal infections, septicemia (infection of the bloodstream), bone and joint infections, skin and soft tissue infections, and meningitis. It is often used for treating infections that are resistant to other antibiotics.
Side effects of Amikacin
Nausea
Muscle weakness
Allergic reactions
Gastrointestinal disturbances
How Amikacin works
Amikacin is an antibacterial medication belonging to the aminoglycoside class.
It operates by entering bacterial cells and binding with a part called the 30S ribosomal subunit. This causes an interruption in the process of how bacteria make proteins, which is essential for their survival. By disrupting the bacterial protein synthesis, Amikacin helps to stop the growth and spread of bacteria, thereby aiding in managing bacterial infection.
Certified content
Written By
Doctor of Medicine
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Amikacin is available in the form of a solution for intramuscular or intravenous routes (injection) and a solution (inhalation).
Age and Dose Restrictions
Amikacin is a powerful antibiotic medication that can be used by both adults and children.
Contraindications
Amikacin is contraindicated in patients with known allergy to it or other aminoglycosides. It is also contraindicated in patients with myasthenia gravis, as aminoglycosides may exacerbate muscle weakness.
Other Medications to Avoid
Amikacin may interact with loop diuretics (such as furosemide), nephrotoxic medicines (such as amphotericin B, and cisplatin) and ototoxic medicines (like ethacrynic acid, and vancomycin).
Overdose and Missed Dose
An overdose of Amikacin may cause serious health problems such as kidney damage, hearing loss, and disturbances in balance. If you suspect an overdose, immediately contact your doctor.
If you miss a dose of Amikacin, take it as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not double up on doses to make up for a missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Regular monitoring of kidney function and hearing can help manage possible side effects.
If you experience gastrointestinal disturbances like nausea, vomiting, and diarrhoea, ensure that you stay hydrated.
Use in Driving and Operating Machinery
Amikacin does not generally affect the ability to drive or operate machinery. However, if you feel dizzy or unsteady after administering the medication, avoid these activities until you feel better.
Use in Pregnancy and Lactation
Amikacin falls under the category D of medications for use during pregnancy. It should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. It is recommended to consult a doctor before using Amikacin during breastfeeding.
Caution in Other Conditions
Patients with pre-existing kidney conditions should use Amikacin with caution since it can cause kidney damage.
It should also be used with caution in patients with auditory or vestibular dysfunction due to its ototoxic effects.
Special Dietary and Lifestyle Recommendations
To manage the underlying bacterial infections for which Amikacin is administered, it is important to maintain a healthy lifestyle.
Regular hand-washing and maintaining good personal hygiene can prevent the spread of bacterial infections.
Regularly scheduled check-ups with your doctor can help monitor the progress of treatment and adjust medication if required.
Frequently asked questions
Does Amikacin have any impact on mood?
There is no established correlation between the use of Amikacin and mood changes; however, if you experience any such abnormal changes, consult your doctor immediately.
Can I become addicted to Amikacin?
No, addiction to Amikacin has not been reported. It is an antibiotic used to manage bacterial infections.
Is there a natural alternative to Amikacin?
No natural alternatives with similar effectiveness exist for antibiotics like Amikacin.
Does Amikacin have any effect on sleep?
There is no direct evidence that Amikacin affects sleep patterns. However, if you experience any unusual changes in your sleep after starting this medication, consult your doctor immediately.
Can Amikacin affect fertility?
Amikacin does not directly impact fertility. However, if you are planning to conceive, discuss with your doctor to understand any potential risks associated with its use.
Can I take Amikacin every day?
Amikacin should be taken as directed by your doctor. Overuse or misuse of antibiotics can lead to resistance, making infections harder to manage in the future.
How quickly does Amikacin start working?
Amikacin starts working soon after it is taken, but the time to see improvements in your symptoms can vary depending on the type and severity of the infection.
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