Amantadine
Uses of Amantadine
The primary use of Amantadine is to manage the symptoms of Parkinson's disease such as tremors, rigidity, and slowness of movement (bradykinesia). It belongs to the group of dopamine agonists, which are medicines that increase the levels of dopamine, a neurotransmitter in the brain that regulates movement.
Apart from Parkinson's disease, Amantadine is also indicated for the treatment and prevention of Influenza A infections due to its antiviral properties. It may be used for the treatment of viral respiratory tract infections and other conditions as determined by your doctor.
Side effects of Amantadine
Nausea and vomiting
Dizziness and lightheadedness
Insomnia
Dry mouth
Fatigue
How Amantadine works
Amantadine is a dopamine agonist.
It increases the levels of dopamine, a neurotransmitter in the brain that regulates movement. This helps manage the symptoms of diseases like Parkinson's by improving control over movements. In addition to its dopamine-enhancing action, Amantadine possesses antiviral properties. It blocks the replication of the Influenza A virus, curbing its spread and helping manage viral infections. Through these dual actions, Amantadine helps manage both neurological and viral conditions effectively.
Certified content
Written By
BDS, MDS
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Amantadine can be taken orally (tablet, syrup and capsule).
Age and Dose Restrictions
This medicine is generally suitable for adults and children over 1 year of age.
Contraindications
Amantadine is contraindicated in patients who have a known hypersensitivity to the medication or any of its components. Additionally, it is contraindicated in patients with severe renal impairment and untreated angle-closure glaucoma.
Other Medications to Avoid
Amantadine can interact with anticholinergic medications (such as atropine, and scopolamine), diuretics (like furosemide, and hydrochlorothiazide), other dopaminergic medicines (such as levodopa, and carbidopa), and stimulant medications (like methylphenidate, dextroamphetamine).
Overdose and Missed Dose
An overdose of Amantadine may cause symptoms such as agitation, hallucinations, and heart problems. If you suspect an overdose, seek immediate medical attention.
In case you miss a dose of Amantadine, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage nausea or vomiting, try taking Amantadine with a meal or snack.
If dizziness or lightheadedness occurs, sit or lie down until the symptoms pass. Avoid sudden changes in position to prevent falls.
Drink plenty of water to mitigate the side effects of dry mouth.
Use in Driving and Operating Machinery
Amantadine may cause dizziness, blurred vision, or other side effects that could impair your ability to drive or operate machinery. It is advised not to drive or operate heavy machinery until you know how this medicine affects you.
Use in Pregnancy and Lactation
Pregnant women should only use it if the potential benefits outweigh the risks. Amantadine is excreted in breast milk, so it is advised to consult a doctor before using it during breastfeeding.
Caution in Other Conditions
Patients with a history of seizures or psychiatric disorders should use this medication with caution.
It should also be used with caution in patients with cardiovascular disorders, as some cases have shown that Amantadine may worsen heart conditions.
Special Dietary and Lifestyle Recommendations
Adequate hydration is recommended while taking Amantadine, particularly to manage side effects like dry mouth.
Frequently asked questions
Is Amantadine a painkiller?
No, Amantadine is not a painkiller. It is a medicine used to manage Parkinson's disease and certain viral infections.
Will Amantadine affect my mood?
Some individuals taking Amantadine may experience mood changes such as anxiety and nervousness as side effects. If you notice any change in your mood, please consult your doctor.
Does Amantadine affect menstruation?
Amantadine is not directly associated with affecting menstrual changes. However, if you observe any unusual changes in your menstrual cycle while taking this medicine, it is always best to consult your doctor.
Can I take Amantadine without food?
Yes, Amantadine can be taken with or without food. However, taking it with food may help reduce stomach-related side effects.
Is there a risk of dependency on Amantadine?
Amantadine is not known to cause physical or psychological dependence. However, stopping the medication suddenly may worsen Parkinson's symptoms, so it is always advisable to consult your doctor before discontinuing the medicine.
Are there any natural alternatives to Amantadine?
There are no direct natural alternatives to Amantadine. It is essential to follow your doctor's advice regarding managing Parkinson's and Influenza A infections.
Can I take vitamin supplements while using Amantadine?
Yes, you can take vitamin supplements while using Amantadine, but you should inform your doctor about all the medications and supplements you are taking to avoid any potential interactions.
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