Agomelatine
Uses of Agomelatine
Agomelatine is primarily used to manage major depressive episodes in adult. It belongs to the group of atypical antidepressants.
Additionally, it may be beneficial for individuals with depression who also present with prominent sleep complaints or anxiety symptoms.
Side effects of Agomelatine
Headaches
Dizziness
Fatigue
Anxiety
Abdominal pain
How Agomelatine works
Agomelatine is an atypical antidepressant.
It works by acting as a melatonin receptor agonist, meaning it mimics the activity of melatonin in the brain. When our natural sleep and wake cycles or circadian rhythms get disrupted in depression, Agomelatine helps to resynchronise them.
Additionally, Agomelatine acts as a 5-HT2C receptor antagonist. This means it blocks these receptors, leading to an increase in dopamine and norepinephrine levels in the frontal cortex of the brain without affecting serotonin release. This helps to reduce depressive symptoms, while avoiding certain side effects associated with other antidepressants.
Therefore, Agomelatine's unique dual action addresses both the mood and sleep disturbances associated with depression, offering a distinct advantage over some other antidepressants.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Agomelatine is available as tablets for oral administration.
Age and Dose Restrictions
- This medicine is recommended for the treatment of depressive episodes in adults only.
Contraindications
- Agomelatine is contraindicated in patients with known allergies to the medicine or any of its components.
It should not be used by individuals who have hepatic impairment or active liver disease.
Other Medications to Avoid
- Agomelatine may interact with strong inhibitors of CYP1A2 enzyme (e.g., fluvoxamine and ciprofloxacin), and moderate inhibitors (e.g., estrogen-containing oral contraceptives and paroxetine).
It is important to consult your doctor before starting any prescription or over-the-counter medications while taking Agomelatine.
Overdose and Missed Dose
- An overdose of Agomelatine can lead to an increase in its side effects, such as headache, dizziness, and somnolence. If you suspect an overdose, seek medical attention immediately.
If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take an extra dose to compensate for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
- Drinking plenty of water can help reduce some side effects like dry mouth.
- Try taking the medication at bedtime if it causes drowsiness.
Maintaining a regular sleep schedule can help manage sleep-related side effects.
Use in Driving and Operating Machinery
Agomelatine may cause dizziness or somnolence. If you experience these side effects, refrain from driving or operating heavy machinery until you feel alert again.
Use in Pregnancy and Lactation
Agomelatine is not recommended for use during pregnancy or lactation. Always consult your doctor before using this medication if you are pregnant, planning a pregnancy, or breastfeeding.
Caution in Other Conditions
- Agomelatine should be used with caution in elderly patients over 75 years of age due to limited data.
- Patients with a history of mania or hypomania should be cautious while taking Agomelatine as it may precipitate a manic episode.
It should also be used with caution in patients with severe renal impairment or liver disease
Special Dietary and Lifestyle Recommendations
- Regular physical activity can help manage depressive symptoms and improve your mood.
- Aim to establish regular sleep patterns which can help regulate the body's circadian rhythm.
- Limit intake of caffeine and alcohol which can interfere with sleep and exacerbate depressive symptoms.
- Try to engage in stress-reducing activities such as yoga, meditation, or deep-breathing exercises.
Frequently asked questions
Is Agomelatine an addictive medicine?
No, Agomelatine is not addictive. However, it is important to take this medication exactly as prescribed by your doctor.
What are the alternatives to Agomelatine if it does not work for me?
If Agomelatine does not work for you, your doctor may consider other antidepressant medications. It is important to discuss this with your doctor.
Does Agomelatine affect appetite?
While some people might experience changes in their appetite while taking Agomelatine, it is not a common side effect. However, if you notice any significant changes, please consult your doctor.
Can I take herbal supplements while on Agomelatine?
It depends on the type of herbal supplement. Some herbal supplements can interact with Agomelatine and may cause side effects. Always consult your doctor before starting any new medication or supplement.
Can I consume alcohol while taking Agomelatine?
It is generally recommended to avoid alcohol while taking any antidepressant medication, including Agomelatine. Alcohol can increase the risk of side effects and can also worsen depression.
Does Agomelatine have any impact on my mood apart from treating depression?
Agomelatine primarily works by treating depression. It may improve your mood as part of the overall improvement in depressive symptoms.
Can I take Agomelatine if I have allergies?
If you have a known allergy to Agomelatine or any of its components, you should not take this medication. Always inform your doctor about your allergies before starting a new medication.
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