Ademetionine
Uses of Ademetionine
Ademetionine is primarily used for managing liver diseases such as intrahepatic cholestasis and biliary cholangitis. It belongs to a group of an organic compound known as 5'-deoxy-5'-thionucleosides.
Additionally, this medicine is utilised for managing depression due to its potential antidepressant effects. It is also effective in managing osteoarthritis (degenerative joint disease), as it stimulates the production of cartilage components, reduces inflammatory mediators and possesses pain-killing properties.
Side effects of Ademetionine
Abdominal discomfort
Abdominal pain
Diarrhoea
Nausea
Dizziness
How Ademetionine works
Ademetionine is an organic compound known as 5'-deoxy-5'-thionucleosides.
It serves as a methyl donor in numerous methylation reactions, helping to maintain sufficient levels of the antioxidant glutathione in the liver. This action minimises liver damage and prevents an increase of lipids associated with certain liver conditions. Another aspect of its mechanism involves affecting neurotransmitters, like serotonin, which play a vital role in mood regulation. This interaction potentially contributes to its antidepressant effects.
Certified content
Written By
BDS, MDS
Reviewed By
BAMS, APG, PG
Expert Advice
Dosage Forms Available
Ademetionine is available for use via oral (enteric-coated tablets) and intravascular or intramuscular route (injection).
Age and Dose Restrictions
This medicine is primarily meant for adult use. However, it can be given to children under extreme caution and only if recommended by a doctor.
Contraindications
This medicine is contraindicated in patients with known allergies to Ademetionine. Patients with bipolar depression and certain liver diseases like biliary obstruction, liver impairment, variceal bleeding, ascites, and liver encephalopathy should avoid using this medicine.
Other Medications to Avoid
Ademetionine may interact with monoamine oxidase inhibitors (e.g., moclobemide, phenelzine), antidepressants (e.g., bupropion, fluoxetine), antiparkinsonian medicines (e.g., levodopa, carbidopa), and painkillers (e.g., tramadol, acetaminophen).
Overdose and Missed Dose
An overdose of Ademetionine may lead to serious health issues such as constipation, insomnia (difficulty in sleeping) and dizziness. If you suspect an overdose, seek medical attention immediately.
If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Abdominal discomfort or pain can be managed by taking the medication with meals.
Diarrhoea may be managed by drinking plenty of fluids to avoid dehydration.
Use in Driving and Operating Machinery
Ademetionine may cause feelings of dizziness and sleepiness. If you experience these side effects, avoid driving or operating heavy machinery until you feel well enough.
Use in Pregnancy and Lactation
It is recommended to consult a doctor before using Ademetionine during pregnancy or while breastfeeding.
Caution in Other Conditions
Patients suffering from diabetes and Parkinson's disease should exercise caution while taking Ademetionine.
Special Dietary and Lifestyle Recommendations
Avoid high-fat, trans-fat, processed foods, white bread, white pasta, and sugars.
Frequently asked questions
Is Ademetionine a steroid?
No, Ademetionine is not a steroid. It is a naturally occurring substance found in cells, tissues, and bodily fluids.
Does Ademetionine Have Any Effect on Sleep?
Ademetionine may cause insomnia as one of its side effects. This means that some people who take this medicine may find it difficult to sleep.
Will Ademetionine Affect Fertility?
Currently, there is no evidence to suggest that Ademetionine has an effect on fertility. However, if you are planning to conceive, it is best to consult your doctor before taking any medication.
Is It Safe to Take Ademetionine daily?
The duration and frequency of usage will be prescribed by your doctor. It should be followed as per your doctor's advice.
How Much Time Does Ademetionine Take to Work?
The time taken for Ademetionine to show its effects can vary depending on the individual and the condition being managed. Consult your doctor for specific details.
What Is the Best Time to Take Ademetionine?
The best time to take Ademetionine will be determined by your doctor based on your medical condition and response to treatment.
Can alcohol consumption affect the effectiveness of Ademetionine?
Yes, consuming alcohol while taking Ademetionine is not advisable as it may increase drowsiness and risk of liver damage.
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